Acrylamide, workers

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Summary

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Related Topics

• Acrylamide, food

Reports and Studies

• Swaen G et al, Mortality study update of acrylamide workers, Occup Environ Med. 2007 Jun;64(6):396-401. Epub 2007 Jan 25.
  • Abstract. "This study provides little evidence for a cancer risk from occupational exposure to acrylamide at production facilities. However, the increased rates of pancreatic cancer in this study and another larger study of acrylamide production workers indicate that caution is needed to rule out a cancer risk. The authors believe that the excess of diabetes mortality in this study is most likely not related to acrylamide exposure, because a larger study of acrylamide workers reported a deficit in this cause of death. The authors conclude that the increased SMR for diabetes mortality is probably not related to regional influences."
• Marsh G et al., Mortality patterns among workers exposed to acrylamide: updated follow up, J Occup Environ Med. 2007 Jan;49(1):82-95.
  • Abstract. "AMD exposure at the levels present in our study sites was not associated with elevated cancer mortality risks."
• Marsh G et al., Mortality patterns among workers exposed to acrylamide: 1994 follow up, Occup Environ Med. 1999 Mar;56(3):181-90.
  • Abstract. "The contribution of 1115 additional deaths and nearly 60,000 person-years over the 11 year follow up period corroborate the original cohort study findings of little evidence for a causal relation between exposure to acrylamide and mortality from any cancer sites, including those of initial interest. This is the most definitive study of the human carcinogenic potential of exposure to acrylamide conducted to date."
• Collins J et al., Mortality patterns among workers exposed to acrylamide, J Occup Med. 1989 Jul;31(7):614-7.
  • Abstract. "A cohort of 8854 men, 2293 of whom were exposed to acrylamide, was examined from 1925 to 1983 for mortality. This cohort consisted of four plant populations in two countries: the United States and The Netherlands. No statistically significant excess of all-cause or cause-specific mortality was found among acrylamide workers. Analysis by acrylamide exposure levels showed no trend of increased risk of mortality from several cancer sites. These results do not support the hypothesis that acrylamide is a human carcinogen."
• Sobel W et al., Acrylamide cohort mortality study, Br J Ind Med. 1986 Nov;43(11):785-8.
  • Abstract. "The mortality experience of 371 employees assigned to acrylamide monomer and polymerisation operations was examined with particular emphasis on cancers at sites identified from animal studies such as the central nervous system, thyroid gland, other endocrine glands, and mesotheliomas. A total of 29 deaths was observed up until 1982 (38.0 expected). No statistically significant excesses were noted in the total cohort and no deaths were found for the hypothesised sites of cancer. The observed deaths in the total cohort for the all cancers category were somewhat in excess (11 v 7.9); however, this was due entirely to excess cancers of the digestive tract and respiratory system in the subgroup with previous exposure to organic dyes. Among those employees not exposed to organic dyes, four deaths were due to malignancies versus 6.5 expected. This study does not support a cause effect relation between exposure to acrylamide at this work site and overall mortality, total malignant neoplasms, or any specific cancers."