Skin painting studies

From

Summary

TBD.

Studies and Reports

• Tobin P et al., An evaluation of skin painting studies as determinants of tumorigenesis potential following skin contact with carcinogens, Regulatory Toxicology and Pharmacology 2:1;22-37, March 1982.
  • Summary. "The literature was surveyed for reports of skin and systemic tumorigenesis following topical application of carcinogenic chemicals to test animals. The International Agency for Research on Cancer (IARC) monographs, Vols. 1–16 (1972–1978), have designated 247 chemicals as possessing some evidence of carcinogenicity in humans and/or animals. Our survey showed that 51 of these chemicals have been tested for tumorigenesis in animal skin painting studies, and that 36 of the 51 (71%) induced skin tumors in the test animals. Necropsies were performed in the studies of 20 of the 51 chemicals. For these 20 chemicals, 10 of theskin painting tests resulted in skin tumors, and 10 did not. Of the 10 chemicals that caused skin tumors, 5 also induced systemic tumors and 5 did not. Of the 10 chemicals that did not elicit skin tumors, 3 caused systemic tumors and 7 did not. These latter 7 chemicals were completely undetected as carcinogens in the animal skin painting tests, but were determined to be carcinogenic by IARC in studies that involved routes of administration other than the dermal route. Systemic tumor induction in skin painting tests could result in false positives because of oral ingestion by grooming. In conclusion, data in the literature indicate that animal skin painting tests, performed according to current protocols, cannot be conclusively relied upon to determine the potential carcinogenicity of applied chemicals."